Drugs
Needle exchange can/is one of the leading causes of the exposure and contraction of HIV/AIDS. When needles are exchange from person to person and they are not clean, then they can spread diseases. Most times they are spread through drugs, like crack, heroine, etc; but they are also be spread within unclean tattoo needles. Knowing that someone cleans their tools before they are put on or into your body important.
Many rappers from older generations have talked about the epidemic of needle exchange. At one point, drugs were so prevalent, and everyone was doing it, that was the easiest way to contract the virus.
50 Cent alludes to how heroin use can and will eventually kill the addict, and that is often through contraction of AIDS from sharing needles